About Gene List

PF3D7_0518100 (AMR2)

Genome location: Pf3D7_05_v3:753,178..758,036(+)

Genome classification: Core

Function and Localization

Product Description: protein AMR2

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Process GO:0009657 plastid organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.19 0.91
Trophozoite expressed 0.74 0.59
Schizont expressed 0.18 0.89
Gametocyte expressed 0.52 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0518100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.261 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3S7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130134

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 71 23 82
disruptive 57 146 92 221
missense 37 109 76 194

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 118 59 95
disruptive 93 342 171 354
missense 46 262 144 243

PlasmoDB Total SNPs: 223

Non-coding: 74 | Synonymous: 100 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 1379 | Molecular Weight (kDa): 162.82

UniProt ID(s): Q8I3S7

PDB ID(s): None

Isoelectric Point: 7.97

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013584 RAP domain
PFam PF08373 RAP domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
30726238 A mutagenesis screen for essential plastid biogenesis genes in human malariaparasites. Tang Y, Meister TR, ..., Yeh E 10.1371/journal.pbio.3000136