Product Description: SWIB/MDM2 domain-containing protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.36 | 0.79 |
| Schizont | not expressed | 0.75 | 0.60 |
| Gametocyte | not expressed | 0.52 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0518200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.353 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4E7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 4 | 7 |
| disruptive | 0 | 8 | 4 | 12 |
| missense | 0 | 8 | 4 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 6 | 9 |
| disruptive | 2 | 17 | 20 | 37 |
| missense | 0 | 16 | 13 | 23 |
PlasmoDB Total SNPs: 57
Non-coding: 54 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 131 | Molecular Weight (kDa): 15.496
UniProt ID(s): C0H4E7
PDB ID(s): None
Isoelectric Point: 10.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003121 | SWIB/MDM2 domain |
| InterPro | IPR019835 | SWIB domain |
| InterPro | IPR036885 | SWIB/MDM2 domain superfamily |
| PFam | PF02201 | SWIB/MDM2 domain |
| Superfamily | SSF47592 | SWIB/MDM2 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 26791088 | Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues. | Vieira WA, Coetzer TL | 10.1186/s12936-015-1065-9 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |