PF3D7_0518400 (CYC3)

Genome location: Pf3D7_05_v3:762,103..762,792(-)

Genome classification: Core

Function and Localization

Product Description: cyclin, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0005634	nucleus
Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
Process	GO:0051726	regulation of cell cycle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	possibly expressed	0.01	1.00
Schizont	possibly expressed	0.00	1.00
Gametocyte	expressed	0.30	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0518400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.493 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1233200)

Relative Growth Rate: 1.06 ± 0.16
Confidence: 5.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1233200)

Modification: Disrupted | RMgm-3337

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q7K6A7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101636

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	14	5	7
disruptive	3	11	13	19
missense	2	11	12	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	23	5	14
disruptive	13	37	14	54
missense	10	28	13	34

PlasmoDB Total SNPs: 10

Non-coding: 0 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 229 | Molecular Weight (kDa): 26.846

UniProt ID(s): Q7K6A7, Q8T357

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012389	Cyclin P/U
InterPro	IPR013922	Cyclin PHO80-like
InterPro	IPR036915	Cyclin-like superfamily
PFam	PF08613	Cyclin PHO80-like
Superfamily	SSF47954	Cyclin-like superfamily

Associated Publications

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
12869562	Identification and initial characterization of three novel cyclin-relatedproteins of the human malaria parasite Plasmodium falciparum.	Merckx A, Le Roch K, ..., Doerig C	10.1074/jbc.M301625200
26565797	Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during OocystDevelopment in Mosquitoes.	Roques M, Wall RJ, ..., Tewari R	10.1371/journal.ppat.1005273
35881609	Mining transcriptomic data to identify Saccharomyces cerevisiae signaturesrelated to improved and repressed ethanol production under fermentation	Sazegari S, Niazi A, Zinati Z, Eskandari MH	10.1371/journal.pone.0259476
26156140	Cell periphery-related proteins as major genomic targets behind the adaptiveevolution of an industrial Saccharomyces cerevisiae strain to combined heat andhydrolysate stress	Wallace-Salinas V, Brink DP, Ahren D, Gorwa-Grauslund MF	10.1186/s12864-015-1737-4
23338601	Essentiality of respiratory activity for pentose utilization in thermotolerantyeast Kluyveromyces marxianus DMKU 3-1042	Lertwattanasakul N, Suprayogi, ..., Yamada M	10.1007/s10482-012-9874-0