PF3D7_0518600 (WDR26)

Genome location: Pf3D7_05_v3:768,798..774,027(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein 26, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	expressed	0.48	0.72
Schizont	expressed	0.47	0.73
Gametocyte	expressed	1.13	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0518600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.345 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1233400)

Relative Growth Rate: 1.04 ± 0.10
Confidence: 5.94

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1233400)

Modification: Disrupted | RMgm-3339

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3S4

"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.01) with 6Y7O (Global RMSD=5.75)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102395

Most Similar Human Ortholog: C9JCS7

TM-align score: 0.70 | RMSD: 2.56

Seq Identity: 0.26 | Length: 101 / 1276

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000162923	WD repeat domain 26

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	53	34	74
disruptive	43	117	84	200
missense	24	87	71	155

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	126	61	83
disruptive	78	330	165	409
missense	38	227	129	254

PlasmoDB Total SNPs: 262

Non-coding: 119 | Synonymous: 83 | Nonsynonymous: 60 | Stop Codon: 0

Protein Information

Protein Length: 1276 | Molecular Weight (kDa): 150.703

UniProt ID(s): Q8I3S4

PDB ID(s): None

Isoelectric Point: 9.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily