PF3D7_0518800 (PSOP13)

Genome location: Pf3D7_05_v3:783,638..784,991(-)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MAVLFFLFLNMLFYSTNC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	expressed	1.04	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0518800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.972 | MFS: -2.538 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1233600)

Relative Growth Rate: 0.98 ± 0.15
Confidence: 5.13

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1233600)

Modification: Disrupted | RMgm-3340

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4E9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533749

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	9	16
disruptive	5	18	5	33
missense	5	17	4	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	23	12	20
disruptive	9	40	28	82
missense	6	36	24	48

PlasmoDB Total SNPs: 85

Non-coding: 69 | Synonymous: 10 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 203 | Molecular Weight (kDa): 23.516

UniProt ID(s): C0H4E9

PDB ID(s): None

Isoelectric Point: 4.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A