About Gene List

PF3D7_0518900

Genome location: Pf3D7_05_v3:785,664..786,565(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite not expressed 0.00 1.00
Schizont not expressed 0.01 1.00
Gametocyte possibly expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0518900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.185 | MFS: -2.703 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3S0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179330

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 8 5 17
disruptive 0 18 9 26
missense 0 18 8 24

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 20 8 10
disruptive 2 33 29 42
missense 1 28 26 30

PlasmoDB Total SNPs: 27

Non-coding: 17 | Synonymous: 6 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 194 | Molecular Weight (kDa): 22.473

UniProt ID(s): Q8I3S0

PDB ID(s): None

Isoelectric Point: 5.84

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27696623 Novel insights into the composition and function of the Toxoplasma I MC sutures Chen AL, Moon AS, ..., Bradley PJ 10.1111/cmi.12678