PF3D7_0519000 (SLBP)

Genome location: Pf3D7_05_v3:788,099..790,045(+)

Genome classification: Core

Function and Localization

Product Description: histone RNA hairpin-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0071204	histone pre-mRNA 3'end processing complex
Component	GO:0005634	nucleus
Function	GO:0071207	histone pre-mRNA stem-loop binding
Function	GO:0003729	mRNA binding
Process	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage
Process	GO:0051028	mRNA transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.19	0.89
Schizont	possibly expressed	0.03	0.98
Gametocyte	not expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0519000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.138 | MFS: -3.207 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1233800)

Relative Growth Rate: 0.65 ± 0.12
Confidence: 5.59

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1233800)

Modification: Disrupted | RMgm-3341

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3R9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142634

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	6	14
disruptive	7	21	17	41
missense	7	21	17	40

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	20	9	19
disruptive	11	47	35	72
missense	10	40	32	52

PlasmoDB Total SNPs: 90

Non-coding: 60 | Synonymous: 25 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 293 | Molecular Weight (kDa): 35.706

UniProt ID(s): Q8I3R9

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026502	Histone RNA stem-loop-binding protein SLBP1/SLBP2
InterPro	IPR029344	Histone RNA hairpin-binding protein, RNA-binding domain
PFam	PF15247	Histone RNA hairpin-binding protein, RNA-binding domain
Superfamily	N/A	N/A