PF3D7_0519100

Genome location: Pf3D7_05_v3:790,072..791,204(+)

Genome classification: Core

Function and Localization

Product Description: 50S ribosomal protein L14, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005762	mitochondrial large ribosomal subunit
Component	GO:0005739	mitochondrion
Function	GO:0070180	large ribosomal subunit rRNA binding
Function	GO:0003735	structural constituent of ribosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	expressed	0.18	0.88
Schizont	expressed	0.11	0.92
Gametocyte	expressed	0.14	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0519100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.282 | MFS: -2.673 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1233900)

Relative Growth Rate: 0.08 ± 0.03
Confidence: 8.35

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4F0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142574

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 96

Non-coding: 92 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 124 | Molecular Weight (kDa): 14.033

UniProt ID(s): C0H4F0

PDB ID(s): None

Isoelectric Point: 11.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000218	Ribosomal protein L14P
InterPro	IPR036853	Ribosomal protein L14 superfamily
PFam	PF00238	Ribosomal protein L14P
Superfamily	SSF50193	Ribosomal protein L14 superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21