Product Description: 40S ribosomal protein S24
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.12 | 0.22 |
| Trophozoite | expressed | 2.44 | 0.13 |
| Schizont | expressed | 0.65 | 0.64 |
| Gametocyte | expressed | 1.04 | 0.49 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0519400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.88 | MFS: -2.297 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1234200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3R6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100698
Most Similar Human Ortholog: A0A2R8Y849
TM-align score: 0.96 | RMSD: 1.03
Seq Identity: 0.53 | Length: 131 / 133
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138326 | ribosomal protein S24 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 2 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 1 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 81
Non-coding: 74 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 133 | Molecular Weight (kDa): 15.391
UniProt ID(s): Q8I3R6
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 11.46
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001976 | Ribosomal protein S24e |
| InterPro | IPR012678 | Ribosomal protein L23/L15e core domain superfamily |
| InterPro | IPR018098 | Ribosomal S24e conserved site |
| PFam | PF01282 | Ribosomal protein S24e |
| Superfamily | SSF54189 | Ribosomal protein L23/L15e core domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |