Product Description: CCR4 domain-containing protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030014 | CCR4-NOT complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0000175 | 3'-5'-exoribonuclease activity |
| Function | GO:0004535 | poly(A)-specific ribonuclease activity |
| Process | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.27 | 0.87 |
| Trophozoite | not expressed | 0.94 | 0.51 |
| Schizont | not expressed | 0.32 | 0.80 |
| Gametocyte | not expressed | 0.98 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0519500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.086 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1234300)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1237700)
Modification: Mutated | RMgm-4590
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3R5
"Best" AlphaFill ligand hit: ADN (adenosine, Local RMSD=0.07) with 6RVZ (Global RMSD=4.44)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q6L8Q7 | 2',5'-phosphodiesterase 12 | OrthoMCL BLAST | CHEMBL4556129CHEMBL4556129 |
Ortholog Group (OrthoMCL): OG6_101771
Most Similar Human Ortholog: D6R9H6
TM-align score: 0.68 | RMSD: 3.60
Seq Identity: 0.28 | Length: 190 / 2488
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000113300 | CCR4-NOT transcription complex subunit 6 |
| ENSG00000138767 | CCR4-NOT transcription complex subunit 6 like |
Protein Length: 2488 | Molecular Weight (kDa): 289.412
UniProt ID(s): Q8I3R5
PDB ID(s): None
Isoelectric Point: 7.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005135 | Endonuclease/exonuclease/phosphatase |
| InterPro | IPR036691 | Endonuclease/exonuclease/phosphatase superfamily |
| PFam | PF03372 | Endonuclease/exonuclease/phosphatase |
| Superfamily | SSF56219 | Endonuclease/exonuclease/phosphatase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 103 | 59 | 156 |
| disruptive | 87 | 290 | 194 | 480 |
| missense | 46 | 227 | 169 | 392 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 42 | 233 | 100 | 167 |
| disruptive | 160 | 706 | 354 | 661 |
| missense | 83 | 547 | 279 | 473 |
PlasmoDB Total SNPs: 429
Non-coding: 163 | Synonymous: 153 | Nonsynonymous: 113 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30703164 | Plasmodium male gametocyte development and transmission are critically regulatedby the two putative deadenylases of the CAF1/CCR4/NOT complex. | Hart KJ, Oberstaller J, ..., Lindner SE | 10.1371/journal.ppat.1007164 |
| 15466434 | Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses inSaccharomyces cerevisiae | Traven A, Hammet A, ..., Heierhorst J | 10.1534/genetics.104.030940 |
| 19487562 | The Ccr4-Pop2-NOT mRNA deadenylase contributes to septin organization inSaccharomyces cerevisiae | Traven A, Beilharz TH, ..., Heierhorst J | 10.1534/genetics.109.104414 |