PF3D7_0519600

Genome location: Pf3D7_05_v3:811,849..815,452(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.25	0.88
Trophozoite	expressed	0.51	0.70
Schizont	possibly expressed	0.14	0.90
Gametocyte	not expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0519600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.347 | MFS: -2.545 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3R4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532323

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	34	18	40
disruptive	30	113	49	152
missense	19	90	45	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	62	35	67
disruptive	59	221	116	227
missense	36	176	83	150

PlasmoDB Total SNPs: 261

Non-coding: 79 | Synonymous: 89 | Nonsynonymous: 93 | Stop Codon: 0

Protein Information

Protein Length: 755 | Molecular Weight (kDa): 90.653

UniProt ID(s): Q8I3R4

PDB ID(s): None

Isoelectric Point: 6.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012935	Zinc finger, C3HC-like
PFam	PF07967	Zinc finger, C3HC-like
Superfamily	SSF57924	N/A
Superfamily	SSF81995