PF3D7_0519800

Genome location: Pf3D7_05_v3:819,888..824,376(-)

Genome classification: Core

Function and Localization

Product Description: EELM2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0070577	lysine-acetylated histone binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.46	0.78
Trophozoite	expressed	0.48	0.72
Schizont	expressed	0.12	0.92
Gametocyte	expressed	0.48	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0519800

Resistome Missense Mutations: K575N

Resistome Compounds with Missense Mutations: MMV982556

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.459 | MFS: -2.562 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3R2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532504

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	32	21	37
disruptive	17	90	29	116
missense	10	66	24	97

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	57	23	42
disruptive	41	173	89	159
missense	19	135	69	119

PlasmoDB Total SNPs: 253

Non-coding: 184 | Synonymous: 50 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 668 | Molecular Weight (kDa): 78.291

UniProt ID(s): Q8I3R2

PDB ID(s): None

Isoelectric Point: 5.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR031724	Extended EGL-27 and MTA1 homology domain
PFam	PF15863	Extended EGL-27 and MTA1 homology domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
31728527	Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum.	Hoeijmakers WAM, Miao J, ..., Bartfai R	10.1093/nar/gkz1044