Product Description: 40S ribosomal protein S9, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0036396 | RNA N6-methyladenosine methyltransferase complex |
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Component | GO:0015935 | small ribosomal subunit |
| Component | GO:0032040 | small-subunit processome |
| Function | GO:0003723 | RNA binding |
| Function | GO:0019843 | rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0045903 | positive regulation of translational fidelity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 2.10 | 0.27 |
| Trophozoite | expressed | 2.29 | 0.18 |
| Schizont | expressed | 0.59 | 0.67 |
| Gametocyte | expressed | 1.44 | 0.33 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0520000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -2.999 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3R0
"Best" AlphaFill ligand hit: PAR (crestomycin, Local RMSD=0.04) with 4DR2 (Global RMSD=14.91)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100955
Most Similar Human Ortholog: P46781
TM-align score: 0.97 | RMSD: 1.03
Seq Identity: 0.67 | Length: 188 / 189
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170889 | ribosomal protein S9 |
| ENSG00000274005 | ribosomal protein S9 |
| ENSG00000274626 | ribosomal protein S9 |
| ENSG00000274646 | ribosomal protein S9 |
| ENSG00000274950 | ribosomal protein S9 |
| ENSG00000275323 | ribosomal protein S9 |
| ENSG00000277079 | ribosomal protein S9 |
| ENSG00000277359 | ribosomal protein S9 |
| ENSG00000278081 | ribosomal protein S9 |
| ENSG00000278270 | ribosomal protein S9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 4 | 5 |
| disruptive | 0 | 1 | 0 | 3 |
| missense | 0 | 1 | 0 | 2 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 11 | 6 | 13 |
| disruptive | 0 | 6 | 7 | 33 |
| missense | 0 | 4 | 3 | 22 |
PlasmoDB Total SNPs: 107
Non-coding: 98 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 189 | Molecular Weight (kDa): 22.123
UniProt ID(s): Q8I3R0
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 11.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001912 | Ribosomal protein S4/S9, N-terminal |
| InterPro | IPR002942 | RNA-binding S4 domain |
| InterPro | IPR005710 | Ribosomal protein S4/S9, eukaryotic/archaeal |
| InterPro | IPR018079 | Ribosomal protein S4, conserved site |
| InterPro | IPR022801 | Ribosomal protein S4/S9 |
| PFam | PF00163 | Ribosomal protein S4/S9, N-terminal |
| PFam | PF01479 | RNA-binding S4 domain |
| Superfamily | SSF55174 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31384004 | Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodiumfalciparum blood-stage development. | Baumgarten S, Bryant JM, ..., Scherf A | 10.1038/s41564-019-0521-7 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |