About Gene List

PF3D7_0520100 (PPM9)

Genome location: Pf3D7_05_v3:830,897..834,873(+)

Genome classification: Core

Function and Localization

Product Description: protein phosphatase PPM9, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0003824 catalytic activity
Function GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity
Function GO:0004722 protein serine/threonine phosphatase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.28 0.87
Trophozoite expressed 0.41 0.76
Schizont expressed 0.06 0.96
Gametocyte expressed 0.47 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0520100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.017 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1234900)

  • Relative Growth Rate: 1.00 ± 0.08
  • Confidence: 6.53

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1234900)

Modification: Disrupted | RMgm-3347

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4F2

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.3.16 protein-serine/threonine phosphatase ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_152030

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 26 19 42
disruptive 11 62 42 95
missense 10 60 37 88

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 58 25 38
disruptive 25 145 65 151
missense 18 127 62 128

PlasmoDB Total SNPs: 156

Non-coding: 112 | Synonymous: 25 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 706 | Molecular Weight (kDa): 83.405

UniProt ID(s): C0H4F2

PDB ID(s): None

Isoelectric Point: 7.19

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001932 PPM-type phosphatase domain
InterPro IPR015655 Protein phosphatase 2C family
InterPro IPR036457 PPM-type phosphatase domain superfamily
PFam PF00481 PPM-type phosphatase domain
Superfamily SSF81606 PPM-type phosphatase domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
35083211 Functional Characterization of 17 Protein Serine/Threonine Phosphatases inToxoplasma gondii Using CRISPR-Cas9 System Liang QL, Nie LB, ..., Wang JL 10.3389/fcell.2021.738794