Product Description: protein phosphatase PPM9, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Function | GO:0003824 | catalytic activity |
Function | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity |
Function | GO:0004722 | protein serine/threonine phosphatase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.28 | 0.87 |
Trophozoite | expressed | 0.41 | 0.76 |
Schizont | expressed | 0.06 | 0.96 |
Gametocyte | expressed | 0.47 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0520100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.017 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1234900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1234900)
Modification: Disrupted | RMgm-3347
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4F2
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 9 | 26 | 19 | 42 |
disruptive | 11 | 62 | 42 | 95 |
missense | 10 | 60 | 37 | 88 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 15 | 58 | 25 | 38 |
disruptive | 25 | 145 | 65 | 151 |
missense | 18 | 127 | 62 | 128 |
PlasmoDB Total SNPs: 156
Non-coding: 112 | Synonymous: 25 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 706 | Molecular Weight (kDa): 83.405
UniProt ID(s): C0H4F2
PDB ID(s): None
Isoelectric Point: 7.19
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001932 | PPM-type phosphatase domain |
InterPro | IPR015655 | Protein phosphatase 2C family |
InterPro | IPR036457 | PPM-type phosphatase domain superfamily |
PFam | PF00481 | PPM-type phosphatase domain |
Superfamily | SSF81606 | PPM-type phosphatase domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
35083211 | Functional Characterization of 17 Protein Serine/Threonine Phosphatases inToxoplasma gondii Using CRISPR-Cas9 System | Liang QL, Nie LB, ..., Wang JL | 10.3389/fcell.2021.738794 |