About Gene List

PF3D7_0520200 (MED17)

Genome location: Pf3D7_05_v3:834,812..837,967(-)

Genome classification: Core

Function and Localization

Product Description: mediator of RNA polymerase II transcription subunit 17, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016592 mediator complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.09 0.96
Trophozoite expressed 0.37 0.77
Schizont not expressed 0.07 0.95
Gametocyte not expressed 0.17 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0520200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.005 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Q8

"Best" AlphaFill ligand hit: GTP (guanosine-5'-triphosphate, Local RMSD=0.75) with 8SGD (Global RMSD=24.59)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_176169

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 22 24 35
disruptive 15 81 52 119
missense 15 74 52 111

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 60 26 43
disruptive 25 179 87 142
missense 21 167 79 118

PlasmoDB Total SNPs: 122

Non-coding: 84 | Synonymous: 16 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 697 | Molecular Weight (kDa): 82.395

UniProt ID(s): Q8I3Q8

PDB ID(s): None

Isoelectric Point: 5.08

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
35557691 Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. Iyer UB, Park JE, ..., Featherstone M 10.1021/acsomega.2c00368
33789343 Architectural Mediator subunits are differentially essential for globaltranscription in Saccharomyces cerevisiae Tourigny JP, Schumacher K, ..., Zentner GE 10.1093/genetics/iyaa042
32713254 Synthesis of silver nanoparticles prepared with a dextran-type exopolysaccharidefrom Weissella cibaria MED17 with antimicrobial functions Ispirli H, Sagdic O, Dertli E 10.1080/10826068.2020.1795673