Product Description: U6 snRNA-associated Sm-like protein LSm2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1990726 | Lsm1-7-Pat1 complex |
| Component | GO:0000932 | P-body |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0005688 | U6 snRNP |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005622 | intracellular |
| Component | GO:0005634 | nucleus |
| Component | GO:0071011 | precatalytic spliceosome |
| Component | GO:0005732 | sno(s)RNA-containing ribonucleoprotein complex |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.95 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0520300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.431 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1235100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3Q7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103409
Most Similar Human Ortholog: Q9Y333
TM-align score: 0.92 | RMSD: 1.10
Seq Identity: 0.62 | Length: 95 / 103
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000172850 | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| ENSG00000204392 | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| ENSG00000224979 | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| ENSG00000225998 | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| ENSG00000231502 | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| ENSG00000236826 | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 122
Non-coding: 118 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 103 | Molecular Weight (kDa): 12.056
UniProt ID(s): Q8I3Q7
PDB ID(s): None
Isoelectric Point: 9.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR016654 | U6 snRNA-associated Sm-like protein LSm2 |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27503796 | Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. | Siau A, Huang X, ..., Preiser PR | 10.1038/srep31055 |