About Gene List

PF3D7_0520300 (LSM2)

Genome location: Pf3D7_05_v3:837,998..839,532(+)

Genome classification: Core

Function and Localization

Product Description: U6 snRNA-associated Sm-like protein LSm2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:1990726 Lsm1-7-Pat1 complex
Component GO:0000932 P-body
Component GO:0046540 U4/U6 x U5 tri-snRNP complex
Component GO:0005688 U6 snRNP
Component GO:0071013 catalytic step 2 spliceosome
Component GO:0005622 intracellular
Component GO:0005634 nucleus
Component GO:0071011 precatalytic spliceosome
Component GO:0005732 sno(s)RNA-containing ribonucleoprotein complex
Process GO:0000398 mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.09 0.95
Trophozoite expressed 0.32 0.80
Schizont expressed 0.06 0.96
Gametocyte expressed 0.20 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0520300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.431 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1235100)

  • Relative Growth Rate: 0.10 ± 0.16
  • Confidence: 5.04

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Q7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103409

Most Similar Human Ortholog: Q9Y333

TM-align score: 0.92 | RMSD: 1.10

Seq Identity: 0.62 | Length: 95 / 103

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000172850 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
ENSG00000204392 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
ENSG00000224979 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
ENSG00000225998 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
ENSG00000231502 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
ENSG00000236826 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 1 0
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 122

Non-coding: 118 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 103 | Molecular Weight (kDa): 12.056

UniProt ID(s): Q8I3Q7

PDB ID(s): None

Isoelectric Point: 9.07

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001163 LSM domain, eukaryotic/archaea-type
InterPro IPR010920 LSM domain superfamily
InterPro IPR016654 U6 snRNA-associated Sm-like protein LSm2
PFam PF01423 LSM domain, eukaryotic/archaea-type
Superfamily SSF50182 LSM domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27503796 Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. Siau A, Huang X, ..., Preiser PR 10.1038/srep31055