PF3D7_0520700

Genome location: Pf3D7_05_v3:845,538..848,991(-)

Genome classification: Core

Function and Localization

Product Description: CDC73 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016593	Cdc73/Paf1 complex
Function	GO:0000993	RNA polymerase II complex binding
Process	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
Process	GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.32	0.84
Trophozoite	expressed	0.60	0.66
Schizont	possibly expressed	0.09	0.94
Gametocyte	possibly expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0520700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.795 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Q4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144412

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	48	30	59
disruptive	30	121	61	172
missense	26	112	57	155

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	98	57	78
disruptive	60	274	127	313
missense	40	233	107	236

PlasmoDB Total SNPs: 89

Non-coding: 11 | Synonymous: 38 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 974 | Molecular Weight (kDa): 117.999

UniProt ID(s): Q8I3Q4

PDB ID(s): None

Isoelectric Point: 7.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007852	Cdc73/Parafibromin
InterPro	IPR031336	Cell division control protein 73, C-terminal
PFam	PF05179	Cell division control protein 73, C-terminal
Superfamily	N/A	N/A