About Gene List

PF3D7_0520800

Genome location: Pf3D7_05_v3:849,251..856,116(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.34 0.85
Trophozoite not expressed 1.59 0.31
Schizont expressed 0.63 0.67
Gametocyte not expressed 0.62 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0520800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.898 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1235500)

  • Relative Growth Rate: 0.06 ± 0.07
  • Confidence: 6.78

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8L5

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.28) with 2BVL (Global RMSD=16.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101533

Most Similar Human Ortholog: Q9BT17

TM-align score: 0.29 | RMSD: 6.57

Seq Identity: 0.09 | Length: 159 / 2054

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000148824 mitochondrial ribosome associated GTPase 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 87 48 118
disruptive 34 200 111 289
missense 31 173 107 264

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 30 170 85 119
disruptive 81 413 187 467
missense 54 352 157 343

PlasmoDB Total SNPs: 165

Non-coding: 52 | Synonymous: 64 | Nonsynonymous: 49 | Stop Codon: 0

Protein Information

Protein Length: 2054 | Molecular Weight (kDa): 244.098

UniProt ID(s): A0A5K1K8L5

PDB ID(s): None

Isoelectric Point: 5.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895