About Gene List

PF3D7_0521000

Genome location: Pf3D7_05_v3:858,511..861,445(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.57 0.74
Trophozoite expressed 0.93 0.53
Schizont expressed 0.12 0.93
Gametocyte expressed 1.33 0.37

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0521000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.355 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Q2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532609

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 19 16 31
disruptive 17 68 47 86
missense 14 64 45 79

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 49 17 35
disruptive 34 168 63 160
missense 22 141 59 127

PlasmoDB Total SNPs: 57

Non-coding: 31 | Synonymous: 10 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 518 | Molecular Weight (kDa): 63.009

UniProt ID(s): Q8I3Q2

PDB ID(s): None

Isoelectric Point: 9.94

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16172495 The novel Plasmodium gallinaceum sporozoite protein, Pg93, is preferentiallyexpressed in the nucleus of oocyst sporozoites. Lacrue AN, James AA, Beerntsen BT https://pubmed.ncbi.nlm.nih.gov/16172495/