PF3D7_0521100

Genome location: Pf3D7_05_v3:861,930..867,583(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.13	0.92
Schizont	expressed	0.07	0.96
Gametocyte	not expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0521100

Resistome Missense Mutations: E1331K

Resistome Compounds with Missense Mutations: MMV982556

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.791 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Q1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532351

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	61	52	78
disruptive	16	125	94	233
missense	16	121	93	222

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	120	66	110
disruptive	36	316	164	339
missense	29	285	153	267

PlasmoDB Total SNPs: 205

Non-coding: 111 | Synonymous: 66 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 1526 | Molecular Weight (kDa): 185.062

UniProt ID(s): Q8I3Q1

PDB ID(s): None

Isoelectric Point: 7.98

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A