About Gene List

PF3D7_0521200

Genome location: Pf3D7_05_v3:868,694..869,943(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite not expressed 0.22 0.86
Schizont possibly expressed 0.03 0.98
Gametocyte expressed 0.48 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0521200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.168 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4F4

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=16.26) with 5OXF (Global RMSD=23.04)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160727

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 13 9 19
disruptive 4 22 19 52
missense 4 20 18 50

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 27 13 27
disruptive 9 62 33 71
missense 6 53 29 63

PlasmoDB Total SNPs: 45

Non-coding: 21 | Synonymous: 19 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 328 | Molecular Weight (kDa): 39.838

UniProt ID(s): C0H4F4

PDB ID(s): None

Isoelectric Point: 9.67

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036838 Ribosomal protein S10 domain superfamily
PFam N/A N/A
Superfamily SSF54999 Ribosomal protein S10 domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21