PF3D7_0521300

Genome location: Pf3D7_05_v3:870,142..875,484(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.73	0.67
Trophozoite	not expressed	0.86	0.55
Schizont	not expressed	0.33	0.81
Gametocyte	not expressed	1.24	0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0521300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.514 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1235900)

Modification: Disrupted | RMgm-3351

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3P9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532657

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	59	39	74
disruptive	43	146	105	240
missense	29	116	96	213

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	123	50	82
disruptive	94	341	187	347
missense	43	268	152	267

PlasmoDB Total SNPs: 231

Non-coding: 92 | Synonymous: 101 | Nonsynonymous: 38 | Stop Codon: 0

Protein Information

Protein Length: 1345 | Molecular Weight (kDa): 161.904

UniProt ID(s): Q8I3P9

PDB ID(s): None

Isoelectric Point: 9.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF57850	N/A