Product Description: AFG1-like ATPase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0016887 | ATP hydrolysis activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.12 | 0.92 |
| Schizont | not expressed | 0.14 | 0.91 |
| Gametocyte | not expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0521800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.145 | MFS: -2.685 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1236400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1236400)
Modification: Disrupted | RMgm-3352
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4F6
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=1.27) with 8BNX (Global RMSD=7.48)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101377
Most Similar Human Ortholog: Q8WV93
TM-align score: 0.74 | RMSD: 3.39
Seq Identity: 0.27 | Length: 398 / 635
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135537 | AFG1 like ATPase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 30 | 15 | 32 |
| disruptive | 6 | 33 | 28 | 78 |
| missense | 6 | 32 | 28 | 73 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 55 | 23 | 27 |
| disruptive | 9 | 79 | 64 | 109 |
| missense | 9 | 67 | 56 | 90 |
PlasmoDB Total SNPs: 95
Non-coding: 72 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 1
Protein Length: 635 | Molecular Weight (kDa): 76.831
UniProt ID(s): C0H4F6
PDB ID(s): None
Isoelectric Point: 8.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005654 | ATPase, AFG1-like |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF03969 | ATPase, AFG1-like |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30204084 | Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase | Seidi A, Muellner-Wong LS, ..., van Dooren GG | 10.7554/eLife.38131 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |