About Gene List

PF3D7_0521900

Genome location: Pf3D7_05_v3:888,657..895,144(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite not expressed 0.18 0.90
Schizont not expressed 0.03 0.98
Gametocyte not expressed 1.08 0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0521900

Resistome Missense Mutations: Y330N, N331K, V332E

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.109 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3P4

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=3.36) with 6JWQ (Global RMSD=36.48)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105151

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 63 37 86
disruptive 32 213 127 323
missense 25 196 120 291

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 132 59 84
disruptive 84 441 231 422
missense 59 374 199 337

PlasmoDB Total SNPs: 258

Non-coding: 75 | Synonymous: 124 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 1775 | Molecular Weight (kDa): 213.169

UniProt ID(s): Q8I3P4

PDB ID(s): None

Isoelectric Point: 6.7

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21