Product Description: transcription initiation factor TFIID subunit 10, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005667 | transcription regulator complex |
| Function | GO:0005515 | protein binding |
| Process | GO:0006366 | transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.38 | 0.81 |
| Trophozoite | possibly expressed | 0.76 | 0.57 |
| Schizont | expressed | 0.34 | 0.78 |
| Gametocyte | not expressed | 0.58 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0522200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.372 | MFS: -0.499 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1236900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3P1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 5 | 3 | 8 |
| disruptive | 1 | 6 | 7 | 11 |
| missense | 1 | 6 | 7 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 15 | 2 | 9 |
| disruptive | 2 | 14 | 19 | 30 |
| missense | 2 | 12 | 15 | 17 |
PlasmoDB Total SNPs: 94
Non-coding: 84 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 3
Protein Length: 116 | Molecular Weight (kDa): 13.633
UniProt ID(s): Q8I3P1
PDB ID(s): None
Isoelectric Point: 4.55
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |
| 31755154 | Secreted protein with altered thrombospondin repeat (SPATR) is essential forasexual blood stages but not required for hepatocyte invasion by the malariaparasite Plasmodium berghei. | Gupta R, Mishra A, ..., Mishra S | 10.1111/mmi.14432 |
| 28994223 | Multiple Taf subunits of TFIID interact with Ino2 activation domains andcontribute to expression of genes required for yeast phospholipid biosynthesis | Hintze S, Engelhardt M, ..., Schuller HJ | 10.1111/mmi.13850 |