About Gene List

PF3D7_0522400

Genome location: Pf3D7_05_v3:907,140..937,000(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.33 0.85
Trophozoite expressed 0.80 0.65
Schizont expressed 2.94 0.16
Gametocyte expressed 2.32 0.15

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0522400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.985 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533679

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 66 373 265 575
disruptive 273 1052 695 1589
missense 214 941 656 1427

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 116 777 416 595
disruptive 490 2278 1084 2129
missense 344 1953 977 1680

PlasmoDB Total SNPs: 779

Non-coding: 126 | Synonymous: 386 | Nonsynonymous: 267 | Stop Codon: 0

Protein Information

Protein Length: 9307 | Molecular Weight (kDa): 1117.185

UniProt ID(s): C0H4F8

PDB ID(s): None

Isoelectric Point: 9.79

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104