Product Description: 50S ribosomal protein L17, apicoplast, putative
SignalP Peptide: MKIWILFFLFCKSVLN
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.31 | 0.80 |
| Schizont | expressed | 0.16 | 0.89 |
| Gametocyte | not expressed | 0.14 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0522500
Resistome Missense Mutations: T49I
Resistome Compounds with Missense Mutations: GNF-Pf-3600, GNF-Pf-5611, MMV084864, MMV1454442
Resistome # Samples with Disruptive Mutations: 19 (19 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -3.131 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1237200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4F9
"Best" AlphaFill ligand hit: SPD (n-(2-amino-propyl)-1,4-diaminobutane, Local RMSD=0.21) with 7A18 (Global RMSD=1.58)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100929
Most Similar Human Ortholog: Q9NRX2
TM-align score: 0.63 | RMSD: 1.91
Seq Identity: 0.29 | Length: 115 / 166
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000158042 | mitochondrial ribosomal protein L17 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 9 | 4 | 13 |
| disruptive | 4 | 5 | 5 | 18 |
| missense | 4 | 5 | 5 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 21 | 7 | 10 |
| disruptive | 5 | 20 | 23 | 41 |
| missense | 4 | 17 | 17 | 29 |
PlasmoDB Total SNPs: 41
Non-coding: 33 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 166 | Molecular Weight (kDa): 19.695
UniProt ID(s): C0H4F9
PDB ID(s): None
Isoelectric Point: 11.32
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000456 | Ribosomal protein L17 |
| InterPro | IPR036373 | Ribosomal protein L17 superfamily |
| PFam | PF01196 | Ribosomal protein L17 |
| Superfamily | SSF64263 | Ribosomal protein L17 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |