PF3D7_0522600

Genome location: Pf3D7_05_v3:939,097..942,014(+)

Genome classification: Core

Function and Localization

Product Description: magnesium transporter NIPA, putative

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	expressed	0.09	0.94
Schizont	expressed	0.69	0.61
Gametocyte	expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0522600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.248 | MFS: -2.62 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1237300)

Relative Growth Rate: 0.96 ± 0.06
Confidence: 6.99

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1240600)

Modification: Disrupted | RMgm-4785

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3N7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106074

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	18	9	40
disruptive	4	9	9	27
missense	4	8	8	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	50	21	43
disruptive	8	44	41	103
missense	6	30	34	69

PlasmoDB Total SNPs: 115

Non-coding: 95 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 483 | Molecular Weight (kDa): 55.564

UniProt ID(s): Q8I3N7

PDB ID(s): None

Isoelectric Point: 7.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008521	Magnesium transporter NIPA
PFam	PF05653	Magnesium transporter NIPA
Superfamily	SSF103481	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
20037583	Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum.	Hu G, Cabrera A, ..., Bozdech Z	10.1038/nbt.1597
22328505	Origin, composition, organization and function of the inner membrane complex ofPlasmodium falciparum gametocytes.	Dearnley MK, Yeoman JA, ..., Dixon MW	10.1242/jcs.099002