Product Description: iron-sulfur cluster assembly protein SufA
SignalP Peptide: MTIHIFLCFLLILKIVNA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005737 | cytoplasm |
| Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Process | GO:0016226 | iron-sulfur cluster assembly |
| Process | GO:0097428 | protein maturation by iron-sulfur cluster transfer |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | possibly expressed | 0.08 | 0.95 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | possibly expressed | 0.07 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0522700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.191 | MFS: -3.728 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1237400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1237400)
Modification: Disrupted | RMgm-3356
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3N6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101081
Most Similar Human Ortholog: A0A1B0GTK6
TM-align score: 0.81 | RMSD: 2.30
Seq Identity: 0.27 | Length: 92 / 177
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135070 | iron-sulfur cluster assembly 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 5 | 7 | 10 |
| disruptive | 1 | 22 | 13 | 31 |
| missense | 1 | 22 | 13 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 12 | 20 |
| disruptive | 5 | 57 | 30 | 61 |
| missense | 4 | 49 | 25 | 40 |
PlasmoDB Total SNPs: 58
Non-coding: 52 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 177 | Molecular Weight (kDa): 20.528
UniProt ID(s): Q8I3N6
PDB ID(s): None
Isoelectric Point: 9.4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000361 | FeS cluster biogenesis |
| InterPro | IPR016092 | FeS cluster insertion protein |
| InterPro | IPR017870 | FeS cluster insertion, C-terminal, conserved site |
| InterPro | IPR035903 | HesB-like domain superfamily |
| PFam | PF01521 | FeS cluster biogenesis |
| Superfamily | SSF89360 | HesB-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 24586983 | Identification of vital and dispensable sulfur utilization factors in thePlasmodium apicoplast. | Haussig JM, Matuschewski K, Kooij TW | 10.1371/journal.pone.0089718 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 32364014 | Molecular dynamics simulation study of Plasmodium falciparum and Escherichia coliSufA: Exploration of conformational changes possibly involved in iron-sulfurcluster transfer | Kadirvel P, Subramanian A, ..., Anishetty S | 10.1080/07391102.2020.1764389 |
| 35164549 | Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparumParasites | Swift RP, Rajaram K, ..., Prigge ST | 10.1128/mbio.03023-21 |