About Gene List

PF3D7_0522800 (BUD31)

Genome location: Pf3D7_05_v3:943,731..945,784(-)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA-splicing factor BUD31, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005686 U2 snRNP
Component GO:0005634 nucleus
Component GO:0005681 spliceosomal complex
Process GO:0008380 RNA splicing
Process GO:0000380 alternative mRNA splicing, via spliceosome
Process GO:0000398 mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.08 0.96
Trophozoite expressed 0.13 0.92
Schizont not expressed 0.02 0.99
Gametocyte possibly expressed 0.08 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0522800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.958 | MFS: -1.984 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1237500)

  • Relative Growth Rate: 0.12 ± 0.18
  • Confidence: 4.85

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3N5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102341

Most Similar Human Ortholog: P41223

TM-align score: 0.93 | RMSD: 1.25

Seq Identity: 0.56 | Length: 142 / 147

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000106245 BUD31 homolog

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 71

Non-coding: 68 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 147 | Molecular Weight (kDa): 17.389

UniProt ID(s): Q8I3N5

PDB ID(s): None

Isoelectric Point: 9.06

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001748 G10 protein
InterPro IPR018230 BUD31/G10-related, conserved site
PFam PF01125 G10 protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
25703931 (1)(1)(3)Cd NMR experiments reveal an unusual metal cluster in the solution structureof the yeast splicing protein Bud31p van Roon AM, Yang JC, ..., Neuhaus D 10.1002/anie.201412210