PF3D7_0522900

Genome location: Pf3D7_05_v3:948,230..953,960(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.06	0.96
Schizont	possibly expressed	0.12	0.93
Gametocyte	expressed	0.68	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0522900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.057 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3N4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
Q9XUB2	Zinc finger protein mex-5	Caenorhabditis elegans	OrthoDB	MLS000075303MLS000033765MLS000072167MLS000073536...

Orthology Information

Ortholog Group (OrthoMCL): OG6_121479

No human ortholog(s)

Protein Information

Protein Length: 1552 | Molecular Weight (kDa): 185.288

UniProt ID(s): Q8I3N4

PDB ID(s): None

Isoelectric Point: 6.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
InterPro	IPR036855	Zinc finger, CCCH-type superfamily
PFam	N/A	N/A
Superfamily	SSF90229	Zinc finger, CCCH-type superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	92	41	99
disruptive	71	257	144	329
missense	36	216	132	272

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	32	167	82	109
disruptive	115	518	226	513
missense	61	439	182	363

PlasmoDB Total SNPs: 246

Non-coding: 87 | Synonymous: 107 | Nonsynonymous: 51 | Stop Codon: 1