Product Description: mitochondrial-processing peptidase subunit alpha, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.24.64 (Mitochondrial processing peptidase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0017087 | mitochondrial processing peptidase complex |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004222 | metalloendopeptidase activity |
| Function | GO:0008121 | ubiquinol-cytochrome-c reductase activity |
| Process | GO:0006627 | protein processing involved in protein targeting to mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.93 |
| Trophozoite | expressed | 0.58 | 0.67 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.46 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0523100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.133 | MFS: -2.983 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3N3
"Best" AlphaFill ligand hit: PEE (dope, Local RMSD=0.34) with 2A06 (Global RMSD=1.92)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.24.64 | mitochondrial processing peptidase | GTPIAAEDTAPCMBRhodaneseMyxothiazolferricyanideantisense RNAdithiothreitolPrepeptide p25Prepeptide p34iodoacetic acid... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102381
Most Similar Human Ortholog: Q10713
TM-align score: 0.83 | RMSD: 2.25
Seq Identity: 0.29 | Length: 460 / 534
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165688 | peptidase, mitochondrial processing subunit alpha |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 22 | 16 | 30 |
| disruptive | 4 | 19 | 15 | 48 |
| missense | 4 | 19 | 15 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 53 | 16 | 23 |
| disruptive | 5 | 69 | 30 | 77 |
| missense | 4 | 58 | 23 | 56 |
PlasmoDB Total SNPs: 84
Non-coding: 64 | Synonymous: 18 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 534 | Molecular Weight (kDa): 61.773
PDB ID(s): None
Isoelectric Point: 8.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007863 | Peptidase M16, C-terminal |
| InterPro | IPR011249 | Metalloenzyme, LuxS/M16 peptidase-like |
| InterPro | IPR011765 | Peptidase M16, N-terminal |
| PFam | PF00675 | Peptidase M16, N-terminal |
| PFam | PF05193 | Peptidase M16, C-terminal |
| Superfamily | SSF63411 | Metalloenzyme, LuxS/M16 peptidase-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 27458014 | The Import of Proteins into the Mitochondrion of Toxoplasma gondii. | van Dooren GG, Yeoh LM, Striepen B, McFadden GI | 10.1074/jbc.M116.725069 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 33576883 | Identification of new proteins related with cisplatin resistance in Saccharomycescerevisiae | Burgos-Molina AM, Mercado-Saenz S, ..., Ruiz-Gomez MJ | 10.1007/s00253-021-11137-w |
| 10873857 | Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeastSaccharomyces cerevisiae co-crystallized with an antibody Fv fragment | Hunte C, Koepke J, ..., Michel H | 10.1016/s0969-2126(00)00152-0 |
| 36791950 | Delving into the molecular initiating event of cadmium toxification via thedose-dependent functional genomics approach in Saccharomyces cerevisiae | Guan M, Wang X, ..., Zhang X | 10.1016/j.envpol.2023.121287 |