PF3D7_0523200

Genome location: Pf3D7_05_v3:965,466..970,150(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.26	0.87
Trophozoite	expressed	0.44	0.74
Schizont	expressed	0.10	0.93
Gametocyte	expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0523200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.115 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1238000)

Relative Growth Rate: 0.11 ± 0.05
Confidence: 7.40

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3N2

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.10) with 7S01 (Global RMSD=14.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532612

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	60	39	68
disruptive	29	158	98	220
missense	26	153	97	197

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	126	50	89
disruptive	52	353	137	326
missense	44	317	126	237

PlasmoDB Total SNPs: 177

Non-coding: 113 | Synonymous: 30 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 1101 | Molecular Weight (kDa): 132.931

UniProt ID(s): Q8I3N2

PDB ID(s): None

Isoelectric Point: 9.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A