PF3D7_0523400

Genome location: Pf3D7_05_v3:973,038..976,138(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.67	0.69
Trophozoite	expressed	1.06	0.46
Schizont	expressed	0.96	0.51
Gametocyte	possibly expressed	1.05	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0523400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.23 | MFS: -2.787 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1238200)

Relative Growth Rate: 0.78 ± 0.07
Confidence: 6.69

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1238200)

Modification: Disrupted | RMgm-3360

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3N0

"Best" AlphaFill ligand hit: 1PS (3-pyridinium-1-ylpropane-1-sulfonate, Local RMSD=1.00) with 5AYK (Global RMSD=8.47)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102152

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	17	15	31
disruptive	4	21	19	41
missense	3	21	19	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	56	23	24
disruptive	10	70	39	120
missense	7	49	30	71

PlasmoDB Total SNPs: 96

Non-coding: 81 | Synonymous: 12 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 533 | Molecular Weight (kDa): 61.903

UniProt ID(s): Q8I3N0

PDB ID(s): None

Isoelectric Point: 8.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR018253	DnaJ domain, conserved site
InterPro	IPR026894	DNAJ-containing protein, X-domain
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF00226	DnaJ domain
PFam	PF14308	DNAJ-containing protein, X-domain
Superfamily	SSF46565	Chaperone J-domain superfamily