PF3D7_0523500

Genome location: Pf3D7_05_v3:976,450..978,046(-)

Genome classification: Core

Function and Localization

Product Description: dynein light chain Tctex-type, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030286	dynein complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.01	0.99
Schizont	no data	0.00	1.00
Gametocyte	no data	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0523500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.994 | MFS: -0.879 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1238300)

Relative Growth Rate: 1.08 ± 0.10
Confidence: 5.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1238300)

Modification: Disrupted | RMgm-3361

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4G0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_115802

Most Similar Human Ortholog: P51808

TM-align score: 0.84 | RMSD: 2.13

Seq Identity: 0.26 | Length: 107 / 113

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000165169	dynein light chain Tctex-type 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	5	8
disruptive	0	2	4	15
missense	0	2	4	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	11	10	7
disruptive	0	21	11	21
missense	0	18	9	17

PlasmoDB Total SNPs: 99

Non-coding: 96 | Synonymous: 0 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 113 | Molecular Weight (kDa): 13.715

UniProt ID(s): C0H4G0

PDB ID(s): None

Isoelectric Point: 4.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005334	Dynein light chain Tctex-1 like
PFam	PF03645	Dynein light chain Tctex-1 like
Superfamily	N/A	N/A