PF3D7_0523600

Genome location: Pf3D7_05_v3:978,381..979,999(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.10	0.93
Schizont	not expressed	0.04	0.96
Gametocyte	not expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0523600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.406 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Q3

"Best" AlphaFill ligand hit: MGR (malachite green, Local RMSD=0.13) with 3BR0 (Global RMSD=19.98)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171412

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	10	5	12
disruptive	2	4	1	12
missense	2	4	1	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	19	9	19
disruptive	2	14	15	50
missense	2	9	12	36

PlasmoDB Total SNPs: 57

Non-coding: 53 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 207 | Molecular Weight (kDa): 24.555

UniProt ID(s): A0A5K1K8Q3

PDB ID(s): None

Isoelectric Point: 8.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A