PF3D7_0523700

Genome location: Pf3D7_05_v3:980,469..986,038(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.94
Trophozoite	not expressed	0.24	0.85
Schizont	not expressed	0.07	0.96
Gametocyte	not expressed	0.57	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0523700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.189 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3M8

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.06) with 6JWR (Global RMSD=20.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532447

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	72	43	103
disruptive	32	176	117	306
missense	28	166	111	275

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	137	72	101
disruptive	63	409	222	368
missense	50	366	190	291

PlasmoDB Total SNPs: 176

Non-coding: 92 | Synonymous: 44 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 1468 | Molecular Weight (kDa): 177.317

UniProt ID(s): Q8I3M8

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A