About Gene List

PF3D7_0523800 (FVRT1)

Genome location: Pf3D7_05_v3:987,076..992,081(+)

Genome classification: Core

Function and Localization

Product Description: food vacuole resident transporter 1

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020020 food vacuole
Component GO:0016020 membrane
Function GO:0015086 cadmium ion transmembrane transporter activity
Function GO:0005384 manganese ion transmembrane transporter activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.20 0.90
Trophozoite not expressed 0.10 0.93
Schizont not expressed 0.04 0.97
Gametocyte not expressed 0.19 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0523800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.016 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3M7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P49281 Natural resistance-associated macrophage protein 2 Homo sapiens OrthoDB CHEMBL1933776CHEMBL1933777CHEMBL1933782CHEMBL1933783...

Orthology Information

Ortholog Group (OrthoMCL): OG6_100775

Most Similar Human Ortholog: F8W154

TM-align score: 0.95 | RMSD: 0.91

Seq Identity: 0.42 | Length: 98 / 684

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000018280 solute carrier family 11 member 1
ENSG00000110911 solute carrier family 11 member 2

Protein Information

Protein Length: 684 | Molecular Weight (kDa): 78.742

UniProt ID(s): Q8I3M7

PDB ID(s): None

Isoelectric Point: 8.78

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001046 NRAMP family
PFam PF01566 NRAMP family
Superfamily N/A N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 42 24 44
disruptive 32 66 31 82
missense 16 56 27 69

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 22 79 23 52
disruptive 54 136 79 169
missense 28 110 64 123

PlasmoDB Total SNPs: 265

Non-coding: 210 | Synonymous: 29 | Nonsynonymous: 25 | Stop Codon: 1

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
35404116 PMRT1, a Plasmodium-Specific Parasite Plasma Membrane Transporter, Is Essentialfor Asexual and Sexual Blood Stage Development. Wichers JS, Mesen-Ramirez P, ..., Strauss J 10.1128/mbio.00623-22