PF3D7_0523900

Genome location: Pf3D7_05_v3:992,760..997,375(-)

Genome classification: Core

Function and Localization

Product Description: MerC domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0523900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.399 | MFS: -2.243 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4G1

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160212

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 186

Non-coding: 169 | Synonymous: 14 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 203 | Molecular Weight (kDa): 23.339

UniProt ID(s): C0H4G1

PDB ID(s): None

Isoelectric Point: 8.32

Protein Domain Annotations: