PF3D7_0524300

Genome location: Pf3D7_05_v3:1,010,595..1,012,862(-)

Genome classification: Core

Function and Localization

Product Description: alpha- and gamma-adaptin-binding protein p34, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.22	0.89
Trophozoite	expressed	0.36	0.78
Schizont	expressed	0.09	0.94
Gametocyte	possibly expressed	0.55	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0524300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.554 | MFS: -2.445 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3M2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533461

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	14	13	20
disruptive	24	65	33	93
missense	19	48	23	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	30	17	25
disruptive	42	137	53	113
missense	35	96	36	77

PlasmoDB Total SNPs: 174

Non-coding: 116 | Synonymous: 31 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 406 | Molecular Weight (kDa): 49.181

UniProt ID(s): Q8I3M2

PDB ID(s): None

Isoelectric Point: 4.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	PF10199	N/A
Superfamily	N/A	N/A