Product Description: 50S ribosomal protein L12, apicoplast, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0015934 | large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.06 | 0.97 |
| Trophozoite | not expressed | 0.57 | 0.67 |
| Schizont | expressed | 0.34 | 0.80 |
| Gametocyte | possibly expressed | 0.56 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0524600
Resistome Missense Mutations: S3R, V4E, S6R
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.957 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3L9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100766
Most Similar Human Ortholog: P52815
TM-align score: 0.44 | RMSD: 3.37
Seq Identity: 0.27 | Length: 106 / 257
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000262814 | mitochondrial ribosomal protein L12 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 7 | 6 | 20 |
| disruptive | 4 | 25 | 12 | 29 |
| missense | 4 | 24 | 11 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 25 | 11 | 15 |
| disruptive | 8 | 57 | 23 | 72 |
| missense | 6 | 44 | 17 | 38 |
PlasmoDB Total SNPs: 97
Non-coding: 88 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 257 | Molecular Weight (kDa): 29.878
UniProt ID(s): Q8I3L9
PDB ID(s): None
Isoelectric Point: 9.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000206 | Ribosomal protein L7/L12 |
| InterPro | IPR008932 | Ribosomal protein L7/L12, oligomerisation |
| InterPro | IPR013823 | Ribosomal protein L7/L12, C-terminal |
| InterPro | IPR014719 | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| InterPro | IPR036235 | Ribosomal protein L7/L12, oligomerisation domain superfamily |
| PFam | PF00542 | Ribosomal protein L7/L12, C-terminal |
| PFam | PF16320 | Ribosomal protein L7/L12, oligomerisation |
| Superfamily | SSF48300 | Ribosomal protein L7/L12, oligomerisation domain superfamily |
| Superfamily | SSF54736 | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |