Genome location: Pf3D7_05_v3:1,018,901..1,020,362(-)
Genome classification: Core
Product Description: mitochondrial import receptor subunit TOM22, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005742 | mitochondrial outer membrane translocase complex |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0006626 | protein targeting to mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.04 | 0.98 |
| Schizont | expressed | 0.00 | 1.00 |
| Gametocyte | expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0524700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.466 | MFS: -2.532 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1239500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3L8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 109
Non-coding: 104 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 105 | Molecular Weight (kDa): 12.017
UniProt ID(s): Q8I3L8
PDB ID(s): None
Isoelectric Point: 10.9
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005683 | Mitochondrial import receptor subunit Tom22 |
| PFam | PF04281 | Mitochondrial import receptor subunit Tom22 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16774588 | Metabolic maps and functions of the Plasmodium mitochondrion. | van Dooren GG, Stimmler LM, McFadden GI | https://pubmed.ncbi.nlm.nih.gov/16774588/ |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 33089990 | Use of Target-Displaying Magnetized Yeast in Screening mRNA-Display PeptideLibraries to Identify Ligands | Bacon K, Bowen J, ..., Menegatti S | 10.1021/acscombsci.0c00171 |
| 31693340 | Screening Yeast Display Libraries against Magnetized Yeast Cell Targets EnablesEfficient Isolation of Membrane Protein Binders | Bacon K, Burroughs M, ..., Rao BM | 10.1021/acscombsci.9b00147 |