PF3D7_0524800 (UFD1)

Genome location: Pf3D7_05_v3:1,020,924..1,024,781(-)

Genome classification: Core

Function and Localization

Product Description: ubiquitin fusion degradation protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.94
Trophozoite	possibly expressed	0.16	0.90
Schizont	possibly expressed	0.20	0.87
Gametocyte	expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0524800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.389 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1239600)

Relative Growth Rate: 1.02 ± 0.09
Confidence: 6.12

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1239600)

Modification: Disrupted | RMgm-3364

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3L7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110149

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	27	23	49
disruptive	8	72	41	118
missense	8	70	41	113

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	80	26	51
disruptive	25	165	91	198
missense	17	149	80	140

PlasmoDB Total SNPs: 270

Non-coding: 230 | Synonymous: 28 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 700 | Molecular Weight (kDa): 82.461

UniProt ID(s): Q8I3L7

PDB ID(s): None

Isoelectric Point: 7.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004854	Ubiquitin fusion degradation protein Ufd1-like
PFam	PF03152	Ubiquitin fusion degradation protein Ufd1-like
Superfamily	N/A	N/A