PF3D7_0525000

Genome location: Pf3D7_05_v3:1,034,754..1,039,424(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol
Component	GO:0005634	nucleus
Function	GO:0003676	nucleic acid binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.11	0.94
Trophozoite	expressed	0.44	0.75
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0525000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -0.466 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1239800)

Relative Growth Rate: 0.15 ± 0.10
Confidence: 6.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3L5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532333

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	49	21	56
disruptive	37	107	50	124
missense	32	87	41	99

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	104	28	46
disruptive	57	228	125	255
missense	49	177	101	160

PlasmoDB Total SNPs: 219

Non-coding: 161 | Synonymous: 25 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 704 | Molecular Weight (kDa): 80.282

UniProt ID(s): Q8I3L5

PDB ID(s): None

Isoelectric Point: 7.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
InterPro	IPR036855	Zinc finger, CCCH-type superfamily
PFam	N/A	N/A
Superfamily	SSF90229	Zinc finger, CCCH-type superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
28288121	A genetic system to study Plasmodium falciparum protein function.	Birnbaum J, Flemming S, ..., Spielmann T	10.1038/nmeth.4223