PF3D7_0525200 (SMC6)

Genome location: Pf3D7_05_v3:1,044,284..1,051,519(+)

Genome classification: Core

Function and Localization

Product Description: structural maintenance of chromosomes protein 6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0525200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.082 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1240000)

• Relative Growth Rate: 0.07 ± 0.06
• Confidence: 7.01

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3L3

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.14) with 3QF7 (Global RMSD=5.40)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102062

Most Similar Human Ortholog: A0A0A0MRY1

TM-align score: 0.46 | RMSD: 5.13

Seq Identity: 0.21 | Length: 273 / 1849

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 464

Non-coding: 153 | Synonymous: 149 | Nonsynonymous: 161 | Stop Codon: 1

Protein Information

Protein Length: 1849 | Molecular Weight (kDa): 217.228

UniProt ID(s): Q8I3L3

PDB ID(s): None

Isoelectric Point: 6.66

Protein Domain Annotations: