PF3D7_0525300

Genome location: Pf3D7_05_v3:1,052,224..1,053,970(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.13	0.94
Trophozoite	expressed	0.04	0.97
Schizont	expressed	0.19	0.90
Gametocyte	expressed	0.32	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0525300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.908 | MFS: -2.321 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3L2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532427

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	26	7	23
disruptive	13	31	32	72
missense	6	26	27	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	39	25	29
disruptive	21	116	67	154
missense	10	86	53	101

PlasmoDB Total SNPs: 68

Non-coding: 28 | Synonymous: 30 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 481 | Molecular Weight (kDa): 55.817

UniProt ID(s): Q8I3L2

PDB ID(s): None

Isoelectric Point: 7.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A