Product Description: 7-helix-1 protein
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0010494 | cytoplasmic stress granule |
| Component | GO:0005829 | cytosol |
| Component | GO:0005887 | integral component of plasma membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0004930 | G protein-coupled receptor activity |
| Function | GO:0005515 | protein binding |
| Function | GO:0043021 | ribonucleoprotein complex binding |
| Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Process | GO:0017148 | negative regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.94 |
| Trophozoite | possibly expressed | 0.33 | 0.79 |
| Schizont | possibly expressed | 0.33 | 0.78 |
| Gametocyte | possibly expressed | 0.50 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0525400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.179 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1240200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1243400)
Modification: Disrupted | RMgm-4755
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3L1
"Best" AlphaFill ligand hit: GSM (s-methyl-glutathione, Local RMSD=0.37) with 8CZL (Global RMSD=2.24)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9NS86 | LanC-like protein 2 | HOGENOM, OrthoDB, OrthoMCL BLAST | CHEMBL3355910 |
Ortholog Group (OrthoMCL): OG6_101476
Most Similar Human Ortholog: O43813
TM-align score: 0.88 | RMSD: 2.49
Seq Identity: 0.31 | Length: 382 / 467
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115365 | LanC like 1 |
| ENSG00000132434 | LanC like 2 |
| ENSG00000147036 | LanC like 3 |
Protein Length: 467 | Molecular Weight (kDa): 55.704
UniProt ID(s): A0A140KKP8, Q8I3L1
PDB ID(s): None
Isoelectric Point: 8.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007822 | Lanthionine synthetase C-like |
| InterPro | IPR020464 | LanC-like protein, eukaryotic |
| PFam | PF05147 | Lanthionine synthetase C-like |
| Superfamily | SSF158745 | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 18 | 17 | 31 |
| disruptive | 6 | 32 | 42 | 85 |
| missense | 6 | 32 | 40 | 78 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 46 | 22 | 33 |
| disruptive | 10 | 124 | 53 | 166 |
| missense | 10 | 105 | 49 | 124 |
PlasmoDB Total SNPs: 75
Non-coding: 39 | Synonymous: 19 | Nonsynonymous: 17 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30133543 | A seven-helix protein constitutes stress granules crucial for regulatingtranslation during human-to-mosquito transmission of Plasmodium falciparum. | Bennink S, von Bohl A, ..., Pradel G | 10.1371/journal.ppat.1007249 |