PF3D7_0525500

Genome location: Pf3D7_05_v3:1,059,480..1,065,703(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.39	0.81
Trophozoite	expressed	0.47	0.75
Schizont	expressed	0.11	0.94
Gametocyte	possibly expressed	0.41	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0525500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.259 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8K0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104214

Most Similar Human Ortholog: C9JFP6

TM-align score: 0.76 | RMSD: 2.05

Seq Identity: 0.11 | Length: 91 / 1863

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000178252	WD repeat domain 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	77	51	91
disruptive	95	280	148	352
missense	55	220	124	274

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	157	64	103
disruptive	191	559	254	511
missense	103	418	204	349

PlasmoDB Total SNPs: 449

Non-coding: 87 | Synonymous: 224 | Nonsynonymous: 138 | Stop Codon: 0

Protein Information

Protein Length: 1863 | Molecular Weight (kDa): 220.938

UniProt ID(s): A0A5K1K8K0

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily