Product Description: RNA methyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.56 (mRNA (guanine-N(7)-)-methyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.71 | 0.60 |
| Schizont | expressed | 0.21 | 0.86 |
| Gametocyte | expressed | 0.55 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0525600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -3.225 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K9E4
"Best" AlphaFill ligand hit: MTA (5'-deoxy-5'-methylthioadenosine, Local RMSD=0.75) with 4X3L (Global RMSD=2.76)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.1.1.56 | mRNA (guanine-N7)-methyltransferase | EDTAGpppGThesitribavirinDigitoninsinefunginTriton X-100deoxycholatecycloheximideS-adenosyl-L-cysteineaurintricarboxylic acidS-adenosyl-homocysteine... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102998
Most Similar Human Ortholog: Q9HC36
TM-align score: 0.68 | RMSD: 3.87
Seq Identity: 0.18 | Length: 283 / 351
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000171861 | mitochondrial rRNA methyltransferase 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 266
Non-coding: 235 | Synonymous: 11 | Nonsynonymous: 18 | Stop Codon: 2
Protein Length: 351 | Molecular Weight (kDa): 41.279
UniProt ID(s): A0A5K1K9E4
PDB ID(s): None
Isoelectric Point: 10.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001537 | tRNA/rRNA methyltransferase, SpoU type |
| InterPro | IPR029028 | Alpha/beta knot methyltransferases |
| PFam | PF00588 | tRNA/rRNA methyltransferase, SpoU type |
| Superfamily | SSF75217 | Alpha/beta knot methyltransferases |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |