Genome location: Pf3D7_05_v3:1,071,094..1,072,988(+)
Genome classification: Core
Product Description: inner membrane complex protein 1g
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.60 | 0.81 |
| Trophozoite | expressed | 0.10 | 0.95 |
| Schizont | expressed | 1.16 | 0.61 |
| Gametocyte | expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0525800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.244 | MFS: -2.655 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1240600)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1243800)
Modification: Tagged | RMgm-4492
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3K7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 13 | 12 | 16 |
| disruptive | 5 | 11 | 4 | 13 |
| missense | 5 | 11 | 4 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 28 | 9 | 23 |
| disruptive | 6 | 26 | 9 | 52 |
| missense | 6 | 20 | 8 | 39 |
PlasmoDB Total SNPs: 99
Non-coding: 81 | Synonymous: 13 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 300 | Molecular Weight (kDa): 34.341
UniProt ID(s): Q8I3K7
PDB ID(s): None
Isoelectric Point: 6.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022086 | Inner membrane complex protein |
| PFam | PF12314 | Inner membrane complex protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 34395314 | Calcium in the Backstage of Malaria Parasite Biology | de Oliveira LS, Alborghetti MR, ..., Charneau S | 10.3389/fcimb.2021.708834 |